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3 unique benefits of methionine


Methionine is an essential amino acid that is vital to human health. Your body cannot produce essential amino acids on its own, so it must be obtained through food in your diet or through supplements. Amino acids are known for their role in the formation of proteins. However, some studies indicate that methionine has additional beneficial roles, creating many other important molecules. We’ll talk more about what methionine is, how it works, and the benefits.

What is methionine

Methionine is one of the nine essential amino acids and the only sulfur containing one that serves as a precursor to all other sulfur-containing amino acids and their derivatives. Although it seems unfair to consider them “non-essential” essential amino acids, they are the ones your body cannot produce on its own.

Methionine is involved in a wide variety of other metabolic reactions in addition to protein formation and its role in muscle protein synthesis, including the production of S-adenosylmethionine (SAM), l-cysteine, glutathione, taurine, sulfate, phospholipids, and in configuration. of creatine and carnitine.

Methionine can be converted into cysteine, which is a semi-essential amino acid and a precursor to an important antioxidant glutathione.

Methionine and cysteine ​​are categorized as sulfur-containing protein-associated amino acids (SAAs). Except for the need for proper protein synthesis, both have a number of physiological and biochemical functions.

The benefits of methionine

1. It may prevent tumor growth

Research indicates that methionine supplementation affects metabolism and reduces tumor aggressiveness in HCC cells, as well as induces activation of both the AMP-activated protein kinase (AMPK) and mTOR pathways. It is shown that a high concentration of methionine impairs and inhibits cell growth, cell migration, and colony formation. Therefore, inhibition of AMPK with methionine supplementation is seen to reduce HCC progression [R].

The meta-analysis has been published in Plus one I studied the effects of colon cancer and methionine. Conclusive evidence has suggested that dietary methionine may reduce the risk of colon cancer, due to methionine’s role in the production of S-adenosyl the active form of methionine. [R].

2. It may help reduce pain

Methionine has been shown to have analgesic benefits. Review published in the journal diseases of the pancreas, selected Eight studies included 411 patients with chronic pancreatitis with study durations ranging from 10 weeks to 12 months. All studies used antioxidants containing methionine, organic selenium, ascorbate, beta-carotene, and alpha-tocopherol.

The results indicated that methionine had a statistically significant effect in reducing pain in patients with cerebral palsy [R].

3. It can cause attention deficit hyperactivity disorder (ADHD)

In the liver, methionine is converted to adenosylate and then converted to S-adenosylmethionine (SAM). SAM is then converted into a compound called s-adenosyl homocysteine ​​(SAH). [R].

S-Adenosyl-L-methionine (SAM), the active form of methionine, acts as a methyl donor and is involved in several metabolic pathways. It has beta-adrenergic and dopamine receptor agonist activity which is critical for heart function.

An open trial using SAM showed that 75% of enrolled patients had symptom improvement with methionine treatment for ADHD. Although this study showed improvement, it was an open trial, with no control group, and a very small sample size of only 8 patients. [R].

Benefits of methionine:

Methionine is an essential sulfur-containing amino acid, which not only helps in the formation of protein, but helps in the formation of many important compounds such as creatine, L-carnitine, Cysteine, glutathione, and taurine. Methionine is easily accessible in protein-rich foods. Adding an Essential Amino Acid (EAA) supplement is also another great way to deliver the muscle building effects associated with EAAs to improve athletic performance and human health.


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